Columbamine is an alkaloid that has been found in Plumeria rubra and has diverse biological activities. It is also a metabolite of berberine (Item No. 10006427). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). It is active against P. falciparum (IC50 = 1.92 µM). It decreases glucose consumption of, and triglyceride levels in, HepG2 cells when used at concentrations of 3 and 15 µM, respectively. Columbamine (56 mg/kg) reduces xylene-induced ear edema and acetic acid-induced writhing in mice.
Columbamine is an alkaloid that has been found in Plumeria rubra and has diverse biological activities. It is also a metabolite of berberine (Item No. 10006427). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). It is active against P. falciparum (IC50 = 1.92 µM). It decreases glucose consumption of, and triglyceride levels in, HepG2 cells when used at concentrations of 3 and 15 µM, respectively. Columbamine (56 mg/kg) reduces xylene-induced ear edema and acetic acid-induced writhing in mice.
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Room Temperature in continental US; may vary elsewhere
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Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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