EC5026 is an inhibitor of soluble epoxide hydrolase (sEH; Ki = <0.05 nM). In vivo, EC5026 (10 mg/kg) increases conditioned place preference for the EC5026-paired chamber, indicating analgesia, in a rodent model of neuropathic pain. It also prevents withdrawal pain in morphine-dependent rats and increases the mechanical paw withdrawal threshold in a rat model of neuropathic pain induced by chronic constriction injury (CCI).
EC5026 is an inhibitor of soluble epoxide hydrolase (sEH; Ki = <0.05 nM). In vivo, EC5026 (10 mg/kg) increases conditioned place preference for the EC5026-paired chamber, indicating analgesia, in a rodent model of neuropathic pain. It also prevents withdrawal pain in morphine-dependent rats and increases the mechanical paw withdrawal threshold in a rat model of neuropathic pain induced by chronic constriction injury (CCI).
Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.
We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.