Naphthol-AS-E-Phosphate

Naphthol AS-E phosphate is an inhibitor of the protein-protein interaction between CREB and the KIX domain of CREB-binding protein (CBP; Ki = 50 µM). It also inhibits the binding of the transcription factor Myb to the KIX domains of p300 and CBP (IC50s = 30 and 43 µM, respectively). Naphthol AS-E phosphate inhibits CREB-dependent transcription in HEK293T cells (Ki = 10 µM). It also decreases the expression of Myb target genes and induces differentiation in HL-60, U937, and NB4 myeloid leukemia cells when used at a concentration of 5 µM. Naphthol AS-E phosphate inhibits proliferation of NCI-H1734...