McNA343

McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays). It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective antagonists. McNA343 also inhibits forskolin-induced cAMP production in CHO cells expressing M1 or M4 receptors, as well as phosphatidylinositol hydrolysis in CHO-K1 cells expressing M3 receptors and CHO cells expressing M5 receptors. Intrathecal administration of McNA343 inhibits compulsive...