Isoconazole-(nitrate)

Isoconazole is an imidazole with antimicrobial activity. It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 2 μg/ml. It is also active against the fungi T. mentagrophytes and T. rubrum when used at a concentration of 0.1 µg/ml and the bacteria C. tuberculostearicum, methicillin-resistant S. aureus (MRSA), and S. epidermis (MICs = 3.9, 32, and 5.6 mg/L, respectively). Isoconazole induces the production of reactive oxygen species (ROS) in S. aureus. It also inhibits...