7-keto-Lithocholic-Acid

7-keto Lithocholic acid is an intermediate in the synthesis of the secondary bile acid ursodeoxycholic acid (Item No. 15121) by intestinal bacteria in humans. It is formed from chenodeoxycholic acid (Item No. 10011286) in B. intestinalis isolated from human feces. Venous infusion of 7-keto lithocholic acid (1.2 µmol/min per 100 g body weight) increases the bile flow rate and the concentration of bile bicarbonate in rats. 7-keto Lithocholic acid levels are decreased in rat feces in a model of adenine-induced chronic renal failure. Fecal levels are also reduced in patients with liver cirrhosis or...