SmgGDS is a chaperone protein and guanine nucleotide exchange factor encoded by RAP1GDS1 that regulates the prenylation and trafficking of small GTPases and has a role in oncogenesis. Alternative splicing of the RAP1GDS1 pre-mRNA produces a full-length isoform, smgGDS-607, and a short isoform, smgGDS-558. SmgGDS-607 is composed of 607 residues and contains an N-terminal nuclear export sequence and multiple armadillo repeats, which are essential for binding to small GTPases that contain a C-terminal polybasic region. It is expressed in a variety of tissues and cancer cell lines. SmgGDS-607 binds...

Shipping & Handling

Shipped In

Wet ice in continental US; may vary elsewhere

Hazardous

Safety & Storage

Storage Temperature

-20°C

Safety Statement

WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Regulatory & Compliance

Technical Documents

Datasheet (1)

pnPUy28945.pdf

MSDS (1)

ClvCy28945m.pdf

Questions & Answers (0)

Citations (0)