Z-VA-DL-D(OMe)--FMK-(trifluoro-acetate-salt)

Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor. It inhibits anti-Fas antibody-induced cleavage of caspase-3 and PARP in Jurkat T lymphocytes when used at a concentration of 0.5 μM. Z-VAD-FMK (50 μM) inhibits cell death induced by TNF-α and cycloheximide co-application in HeLa cells. It also inhibits radiation-induced increases in the number of TUNEL-positive neurons in the rat hypoglossal nucleus when administered intracerebroventricularly at a dose of 2 μg per animal.