(–)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019). In vivo, (–)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg). (–)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity. (–)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 μM for electric eel and rat brain...
(–)-MK-801 is an NMDA receptor antagonist (Ki = 43 nM for inhibition of spermine binding) and an isomer of (+)-MK-801 (Item No. 10009019). In vivo, (–)-MK-801 blocks generalized seizures in a mouse model of epilepsy (ED50 = 0.85 mg/kg) and increases horizontal locomotor activity in mice (ED50 = 2.71 mg/kg). (–)-MK-801 (0.1 mg/kg) decreases immobility time in the tail suspension and forced swim tests in a mouse model of social defeat stress, indicating antidepressant-like activity. (–)-MK-801 also inhibits acetylcholinesterase (AChE) with Ki values of 6.2 and 7.9 μM for electric eel and rat brain...
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Room Temperature in continental US; may vary elsewhere
Hazardous
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Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Hazardous
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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