(E)-Ajoene

(E)-Ajoene is a disulfide that has been found in A. sativum and has diverse biological activities. It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 µg/ml, respectively) and fungi (MICs = 15-50 µg/ml). (E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 µM, respectively). It also inhibits human glutathione reductase and T. cruzi trypanothione reductase when used at a concentration of 200 µM. (E)-Ajoene (25 mg/kg) is neuroprotective in a gerbil...