Urolithin-A

Urolithin A is a secondary metabolite of ellagic acid (Item No. 10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties. It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression. It also potentiates the antiproliferative effect of 5-fluorouracil (Item No. 14416) in Caco-2, SW480, and HT-29 cells. In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin...