SAR405
Cayman Chemical
SKU / CAT#: 16979-1MG
$9300
usd$93.00/mg
SAR405
Cayman Chemical Company, Inc.SKU / CAT#: 16979-1MG
MPN: 16979
$9300
usd$93.00/mg
Available
SHIPS Apr 6th
Available
SHIPS Apr 6th
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Description
SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM). It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation. SAR405 also synergizes with the mTOR inhibitor everolimus (Item No. 11597) in preventing the proliferation of renal tumor cell lines.
SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM). It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation. SAR405 also synergizes with the mTOR inhibitor everolimus (Item No. 11597) in preventing the proliferation of renal tumor cell lines.
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Room Temperature in continental US; may vary elsewhere
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Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
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Datasheet (1)
MSDS (1)
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Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Hazardous
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
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