Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 μM and has an affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 can inhibit pre-RNA splicing with an IC50 value of 0.5 mM and as such has been used to investigate Gcn5/PCAF-like HAT functions during assembly of spliceosome before pre-mRNA translation.
Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 μM and has an affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 can inhibit pre-RNA splicing with an IC50 value of 0.5 mM and as such has been used to investigate Gcn5/PCAF-like HAT functions during assembly of spliceosome before pre-mRNA translation.
Shipping & Handling
Shipped In
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Room Temperature in continental US; may vary elsewhere
Safety & Storage
Storage Temperature
-20°C
Safety Statement
WARNING This product is not for human or veterinary use. Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.
Regulatory & Compliance
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We’re currently in BETA - Interested in joining? Let us know and we’ll get you set up with early access.