Anti-beta 2 Microglobulin Antibody [BBM.1] - BSA and Azide free

Primary

Monoclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

FC, WB, IF, IHC-Fr

BBM.1

beta 2 Microglobulin

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Liquid

1 mg/ml

Mouse

IgG2b

Human, Non-Human Primates

Monoclonal

Unconjugated

Protein A/G chromatography.

FC: 1-2 µg / million cells, WB: 1-2 µg/ml, IF: 1-4 µg/ml, IHC-Fr: 1-2 µg/ml

MOLT-4 human T cell line.

Recognizes a protein of 12kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

kappa

Y