Anti-MUC1 Antibody [MUC1/967] - BSA and Azide free

Primary

Monoclonal

Storing antibodies at various temperatures (up to 40°C) for one week does not affect their activity. As a precautionary measure, we ship all products in insulated packaging with cold packs to provide extra temperature stability in transit. The cold packs may be thawed when you receive the shipment, please be assured that this is normal and your product(s) are safe to use. Once you have received your product(s), please follow the storage instructions on the datasheet(s).

WB, FC, IF, IHC

MUC1/967

MUC1

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Liquid

1 mg/ml

Mouse

IgG1

Human

Monoclonal

Unconjugated

Protein A/G chromatography.

WB: 1-2 µg/ml, FC: 0.5-1 µg / million cells, IF: 1-2 µg/ml, IHC-P: 0.25-0.5 µg/ml

Human milk fat globule membranes.

This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein.The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

kappa

Y