RUNX2 Antibody

Polyclonal

Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.

Canada

WB, IHC, ICC/IF

https://www.ncbi.nlm.nih.gov/gene/860

NP_001019801.3

Non-hazardous

Non-hazardous

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

WB (1:1000), IHC (1:200), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.

Rabbit

IgG

Human | Mouse

Unconjugated

Peptide Affinity Purified

ISO 9001:2015

RUNX2

A synthesized peptide derived from RUNX2

Detects ~56kDa, endogenous levels of total RUNX2

PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated

https://antibodyregistry.org/search.php?q=AB_2713385

Nucleus

Specifically expressed in osteoblasts.

RUNX2 (Runt-related transcription Factor) is a transcription factor that binds to its canonical consensus sequence 5'- PYGPYGGT-3' in a number of promoters and enhancers. Through interaction with Twist 1 and Twist 2, RUNX2 regulates osteocalcin transcription, following parathyroid hormone signaling for bone loss repair. Ossification in skeletal formation is also partially regulated through RUNX2. Essentially, this transcription factor is responsible for many developmental and repair mechanisms in bone and collagen. Mutations in Cbfa1/Runx2 are associated with the disease Cleidocranial dysostosis.

1. Green RE et al. (2010) Science 328 (5979): 710–22. 2. Pockwinse SM et al. (2011) Journal of Cellular Physiology 226 (5): 1383–9. 3. Lian JB. (2004) Critical Reviews in Eukaryotic Gene Expression 14 (1-2): 1–41.

Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Transcription Factors | Stem Cells | Mesenchymal Stem Cells | Osteogenesis

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