Arcyriaflavin-A

Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM). It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively). It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).