Histone Deacetylase 2, CT (HDAC2, Tanscriptional Regulator Homolog RPD3, HD2) (Biotin)

Covalent modification of histone proteins plays an important role in the regulation of gene expression. In particular, acetylation of lysine residue on core histone proteins alters nucleosomal conformation and thereby regulates the accessibility of transcriptional regulatory proteins to chromatin templates. The causal relationship between histone acetylation and gene expression has been furthered by the identification of which posses intrinsic histone acetylase and deacetylase activity. Of the protein which posses intrinsic histone deacetylase activity, the best described are members of a common...