HMGN2 (High Mobility Group (Nonhistone Chromosomal) Protein 17, High Mobility Group nucleosomal Binding Domain 2, High Mobility Group nucleosome-Binding Domain-Containing Protein 2, High Mobility Group Protein N2, HMG17, HMGN2, HMGN2_HUMAN, MGC5629, Non histone Chromosomal Protein HMG 17, Non-histone Chromosomal Protein HMG-17, Nonhistone Chromosomal Protein HMG 17, Nonhistone Chromosomal Protein hmg-17)

The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates. HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence. Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct...