HLA-DPA1 (DP(W3), DP(W4), HLA class II histocompatibility Antigen DP alpha 1 Chain, HLA class II histocompatibility Antigen DP alpha Chain, HLA DP1A, HLA DPA 1, HLA SB alpha Chain, HLADP, HLADPA1, HLASB, HLASB histocompatibility Type, Human MHC class II HLA SB alpha Gene, Major histocompatibility Complex class II DP alpha 1, MHC class II Antigen, MHC class II DP3 alpha, MHC class II DPA1, MHC class II HLA DPA1 Antigen, PLT1, Primed Lymphocyte test 1)

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class IIa/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR,...