ROCK2 (Rho-associated Protein Kinase 2, Rho Kinase 2, Rho-associated, Coiled-coil-containing Protein Kinase 2, p164 ROCK-2, KIAA0619) (Biotin)

Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase,which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388aa residues with a calculated molecular mass of approximately 161kD. Fluorescence in situ hybridization...