Specifications
SHIPPING NOTES
Blue Ice or 4ºC. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
APPLICATION
WB, ICC/IF, IHC, ELISA
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
ANTIBODY TYPE
WB (1:1000); ICC/IF (1:50); ELISA (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.
REACTIVITY SPECIES
Species Independent
PURIFICATION
Protein G Purified
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
IMMUNOGEN
Synthetic Sulfotyrosine conjugated to Keyhole Limpet Hemocyanin (KLH).
SPECIFICITY
Specific for sulfated tyrosine residues on various proteins. Does not detect free Sulfotyrosine. Does not cross-react with phosphotyrosine.
STORAGE BUFFER
PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
ANTIBODY ID
https://antibodyregistry.org/search.php?q=AB_2703036
SCIENTIFIC BACKGROUND
Tyrosine sulfation is a common post-translational protein modification catalyzed by tyrosylprotein sulfotransferase (TPST) (1). Sulfotyrosines mediate interactions between hirudin and thrombin, P-selectin glycoprotein ligand-1 and P-selectin, and von Willebrand factor and factor VIII. Tyrosine sulfation of certain receptors is required for several viruses and parasites to enter their hosts.
REFERENCES
1. Lee, R.W., Huttner W.B. (1983). J Biol Chem. 258(18):11326-34.
RESEARCH AREA
Cell Signaling | Post-translational Modifications | Sulfation
ALTERNATIVE NAMES
Sulfotyrosine Antibody, Tyrosine sulfation Antibody, Sulfated Tyrosine Antibody, S-Tyrosine Antibody, sTYR Antibody, Sulphotyrosine Antibody, Tyrosine Sulphation Antibody, Sulphated Tyrosine Antibody
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