Specifications
SHIPPING NOTES
Shipped Ambient. All orders received in North America by 12:00 PM PST Monday to Thursday will usually be shipped out on the same day. North American customers will typically receive their orders within 1-2 business days. All shipments are F.O.B. from point of shipment, pre-paid and added to the invoice. Freight charges include but not limited to: priority service and packaging materials.Products are shipped with “cold packs” in insulated containers. There is a charge for this packaging and for the shipping costs via FedEx. Please inspect packages immediately upon receipt and inform Labscoop Customer Support of any shortage or damage within 48 hours of receipt. We can only accept returns after we have given prior authorization and issued specific shipping instructions. If a customer wishes to use their own FedEx account number please indicate this on the purchase order or during checkout.
SMILES
COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O
INCHI KEY
VABYUUZNAVQNPG-UHFFFAOYSA-N
*USAGE / SAFETY STATEMENT
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
QUALITY CERTIFICATION / COMPLIANCE
ISO 9001:2015
SCIENTIFIC BACKGROUND
Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).
REFERENCES
1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199.
2. Raj L., et al. (2011) Nature. 475(7355): 231.
RESEARCH AREA
Cancer | Oxidative Stress
ALTERNATIVE NAMES
1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
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